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Interventional Cardiology

Medical & Preventive Cardiology

Lipidology & Atherosclerosis Prevention

CV RISK/DIABETES

A MULTI-SPECIALTY PERSPECTIVE

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Freek W A Verheugt, MD, PhD

Freek W A Verheugt, MD, PhD

Professor of Cardiology

Chairman of the Department of Cardiology

Heartcenter of the University Medical Center

Nijmegen, The Netherlands

As the cost and institutional barriers to deploying PCSK9 inhibitors become less onerous, which patients in a medical cardiology practice represent the most attractive candidates for these agents and their profound LDL-C lowering effects?

As the cost and institutional barriers to deploying PCSK9 inhibitors become less onerous, which patients in a medical cardiology practice represent the most attractive candidates for these agents and their profound LDL-C lowering effects?

Freek W A Verheugt, MD, PhD

Based on the ODYSSEY Outcomes Trial, which enrolled primarily patients with post-ACS, which subset of patients managed in a medical cardiology practice should be thoroughly evaluated for CV risk reduction benefits accruing to PCSK9 inhibitors?

Based on the ODYSSEY Outcomes Trial, which enrolled primarily patients with post-ACS, which subset of patients managed in a medical cardiology practice should be thoroughly evaluated for CV risk reduction benefits accruing to PCSK9 inhibitors?

Freek W A Verheugt, MD, PhD

From your perspective as a medical cardiologist, what impact should the reductions in associated overall mortality reported with alirocumab in the ODYSSEY Outcomes Trial have on selecting a PCSK9 inhibitor?

From your perspective as a medical cardiologist, what impact should the reductions in associated overall mortality reported with alirocumab in the ODYSSEY Outcomes Trial have on selecting a PCSK9 inhibitor?

Freek W A Verheugt, MD, PhD

What would your approach be to a 57-year-old man with an LDL-C of 70 mg/dL who has recently had an ACS event and now develops recurrent ACS, or a new stent thrombosis? Does ODYSSEY Outcomes provide any evidence-based guidance?

What would your approach be to a 57-year-old man with an LDL-C of 70 mg/dL who has recently had an ACS event and now develops recurrent ACS, or a new stent thrombosis? Does ODYSSEY Outcomes provide any evidence-based guidance?

Freek W A Verheugt, MD, PhD

How have the results of ODYSSEY Outcomes—especially as they relate to progressive CV risk reductions in patients with high LDL-C levels who achieve target levels of 50 mg/dL or less—support the “treat-to-target” approach to lipid management?

How have the results of ODYSSEY Outcomes—especially as they relate to progressive CV risk reductions in patients with high LDL-C levels who achieve target levels of 50 mg/dL or less—support the “treat-to-target” approach to lipid management?

Freek W A Verheugt, MD, PhD

In the subpopulation of high-risk patients—individuals with post-ACS, patients with diabetes, post-PCI and others—is there enough compelling evidence from the PCSK9 trials that the “LDL hypothesis” is a proven fact?

In the subpopulation of high-risk patients—individuals with post-ACS, patients with diabetes, post-PCI and others—is there enough compelling evidence from the PCSK9 trials that the “LDL hypothesis” is a proven fact?

Freek W A Verheugt, MD, PhD

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